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"Our work challenges the textbook mannequin of how the brain fuels itself. Neurons are more self-ample than we thought," Singh stated. Co-writer Daniel Colón-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at YSM, said the research helps the notion of glycogen as an "energy capacitor" in neurons. "Just like in muscles, this reserve can buffer speedy shifts in energy demand," Colón-Ramos stated. Other authors, all from Yale, include Sarah Emerson, a postdoctoral researcher in neuroscience; Ian J. Gonzalez, a graduate student in cell biology; Anjali A. Vishwanath and Anastasia Tsives, submit-doctoral researchers in neuroscience; and Richard Goodman, a analysis scientist in neuroscience. Original Research: Open access. "Glycogen helps glycolytic plasticity in neurons" by Milind Singh et al. Glycogen is the biggest power reserve in the mind, however the precise position of glycogen in supporting neuronal power metabolism in vivo is not nicely understood. We performed an RNAi screen and identified that PYGL-1, an ortholog of the human glycogen phosphorylase, is required in neurons for glycolytic plasticity. We decided that neurons make use of at the least two mechanisms of glycolytic plasticity: glycogen-dependent glycolytic plasticity (GDGP) and glycogen-impartial glycolytic plasticity. We uncover that GDGP is employed below situations of mitochondrial dysfunction, such as transient hypoxia or in mutants for mitochondrial function.

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